ChloroquineV1, France, Analysis, bibRecord, 000174

Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study.

Identifieur interne : 000174 ( France/Analysis ); précédent : 000173; suivant : 000175

Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study.

Auteurs : Marie Varela [Sénégal] ; Romy Razakandrainibe [Madagascar] ; Delphine Aldebert [France] ; Jean Christophe Barale [France] ; Ronan Jambou [Madagascar]

Source :

Malaria Journal [ 1475-2875 ] ; 2014.

RBID : Hal:pasteur-00971508

Abstract

BACKGROUND: A flow cytometric method is proposed to study in vitro drug sensitivity of Plasmodium falciparum. Standard [3H]-hypoxanthine incorporation assay gives only information on inhibition of maturation by drugs. This method is usable on field isolates and provides data on both inhibition of maturation and re-invasion. METHODS: The method is based on the staining of parasites with hydroethidine (HE) and thiazole orange (TO) which allow differential identification of early, trophozoite and late stage of the parasite by flow cytometry. Late stages of the parasites are obtained by incubation in culture for 24 hours. Reinvasion is followed by culturing parasitized red blood cells for 24 h more. RESULTS: Compared to the standard [3H]-hypoxanthine incorporation assay, it gave similar results as expressed by 50% inhibitory concentrations for chloroquine of laboratory strains and "field" isolates. The effect of quinine on the schizont-ring transition was also explored using this method. First data on the inhibition of re-invasion induced by quinine are presented for both P. falciparum-cultured strains and field isolates. DISCUSSION: This method is simple to use event for field isolate study. It is suitable to analyse effect of drugs on steps of the parasite life cycle different for the maturation one. Using this method quinine was found to have a inhibitory effect on re-invasion of red cells by Plasmodium.

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-00971508

DOI: 10.1186/1475-2875-13-110

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000060
to stream Hal, to step Curation: 000060
to stream Hal, to step Checkpoint: 000125
to stream Main, to step Merge: 001002
to stream Main, to step Curation: 001001
to stream Main, to step Exploration: 001001
to stream France, to step Extraction: 000174

Links to Exploration step

Hal:pasteur-00971508

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study.</title>
<author><name sortKey="Varela, Marie" sort="Varela, Marie" uniqKey="Varela M" first="Marie" last="Varela">Marie Varela</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-42095" status="VALID">          <orgName>Institut Pasteur de Dakar</orgName>
          <desc>            <address>              <addrLine>B.P. 220 Dakar</addrLine>
              <country key="SN"></country>
            </address>
            <ref type="url">http://www.pasteur.sn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Sénégal</country>
</affiliation>
</author>
<author><name sortKey="Razakandrainibe, Romy" sort="Razakandrainibe, Romy" uniqKey="Razakandrainibe R" first="Romy" last="Razakandrainibe">Romy Razakandrainibe</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-55578" status="VALID">          <orgName>Institut Pasteur de Madagascar</orgName>
          <desc>            <address>              <addrLine>B.P. 1274 Antananarivo</addrLine>
              <country key="MG"></country>
            </address>
            <ref type="url">http://www.pasteur.mg</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Madagascar</country>
</affiliation>
</author>
<author><name sortKey="Aldebert, Delphine" sort="Aldebert, Delphine" uniqKey="Aldebert D" first="Delphine" last="Aldebert">Delphine Aldebert</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-644" status="VALID">          <orgName>Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble]</orgName>
          <orgName type="acronym">LAPM</orgName>
          <desc>            <address>              <addrLine>Institut Jean Roget BP 170 38042 GRENOBLE CEDEX 9</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://merci-gscol1.ujf-grenoble.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-51016" type="direct"></relation>
            <relation name="UMR5163" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD">          <idno type="IdRef">026404796</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>            <address>              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR5163" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
<author><name sortKey="Barale, Jean Christophe" sort="Barale, Jean Christophe" uniqKey="Barale J" first="Jean Christophe" last="Barale">Jean Christophe Barale</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-28152" status="OLD">          <orgName>Immunologie moléculaire des parasites</orgName>
          <desc>            <address>              <addrLine>25-28 rue du Docteur Roux F-75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.pasteur.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
            <relation name="UMR2581" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR2581" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Jambou, Ronan" sort="Jambou, Ronan" uniqKey="Jambou R" first="Ronan" last="Jambou">Ronan Jambou</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-55578" status="VALID">          <orgName>Institut Pasteur de Madagascar</orgName>
          <desc>            <address>              <addrLine>B.P. 1274 Antananarivo</addrLine>
              <country key="MG"></country>
            </address>
            <ref type="url">http://www.pasteur.mg</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Madagascar</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:pasteur-00971508</idno>
<idno type="halId">pasteur-00971508</idno>
<idno type="halUri">https://hal-pasteur.archives-ouvertes.fr/pasteur-00971508</idno>
<idno type="url">https://hal-pasteur.archives-ouvertes.fr/pasteur-00971508</idno>
<idno type="doi">10.1186/1475-2875-13-110</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Hal/Corpus">000060</idno>
<idno type="wicri:Area/Hal/Curation">000060</idno>
<idno type="wicri:Area/Hal/Checkpoint">000125</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000125</idno>
<idno type="wicri:doubleKey">1475-2875:2014:Varela M:cytometric:measurement:of</idno>
<idno type="wicri:Area/Main/Merge">001002</idno>
<idno type="wicri:Area/Main/Curation">001001</idno>
<idno type="wicri:Area/Main/Exploration">001001</idno>
<idno type="wicri:Area/France/Extraction">000174</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study.</title>
<author><name sortKey="Varela, Marie" sort="Varela, Marie" uniqKey="Varela M" first="Marie" last="Varela">Marie Varela</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-42095" status="VALID">          <orgName>Institut Pasteur de Dakar</orgName>
          <desc>            <address>              <addrLine>B.P. 220 Dakar</addrLine>
              <country key="SN"></country>
            </address>
            <ref type="url">http://www.pasteur.sn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Sénégal</country>
</affiliation>
</author>
<author><name sortKey="Razakandrainibe, Romy" sort="Razakandrainibe, Romy" uniqKey="Razakandrainibe R" first="Romy" last="Razakandrainibe">Romy Razakandrainibe</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-55578" status="VALID">          <orgName>Institut Pasteur de Madagascar</orgName>
          <desc>            <address>              <addrLine>B.P. 1274 Antananarivo</addrLine>
              <country key="MG"></country>
            </address>
            <ref type="url">http://www.pasteur.mg</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Madagascar</country>
</affiliation>
</author>
<author><name sortKey="Aldebert, Delphine" sort="Aldebert, Delphine" uniqKey="Aldebert D" first="Delphine" last="Aldebert">Delphine Aldebert</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-644" status="VALID">          <orgName>Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble]</orgName>
          <orgName type="acronym">LAPM</orgName>
          <desc>            <address>              <addrLine>Institut Jean Roget BP 170 38042 GRENOBLE CEDEX 9</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://merci-gscol1.ujf-grenoble.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-51016" type="direct"></relation>
            <relation name="UMR5163" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD">          <idno type="IdRef">026404796</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>            <address>              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR5163" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
<author><name sortKey="Barale, Jean Christophe" sort="Barale, Jean Christophe" uniqKey="Barale J" first="Jean Christophe" last="Barale">Jean Christophe Barale</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-28152" status="OLD">          <orgName>Immunologie moléculaire des parasites</orgName>
          <desc>            <address>              <addrLine>25-28 rue du Docteur Roux F-75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.pasteur.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
            <relation name="UMR2581" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR2581" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Jambou, Ronan" sort="Jambou, Ronan" uniqKey="Jambou R" first="Ronan" last="Jambou">Ronan Jambou</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-55578" status="VALID">          <orgName>Institut Pasteur de Madagascar</orgName>
          <desc>            <address>              <addrLine>B.P. 1274 Antananarivo</addrLine>
              <country key="MG"></country>
            </address>
            <ref type="url">http://www.pasteur.mg</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Madagascar</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1186/1475-2875-13-110</idno>
<series><title level="j">Malaria Journal</title>
<idno type="ISSN">1475-2875</idno>
<imprint><date type="datePub">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>BACKGROUND: A flow cytometric method is proposed to study in vitro drug sensitivity of Plasmodium falciparum. Standard [3H]-hypoxanthine incorporation assay gives only information on inhibition of maturation by drugs. This method is usable on field isolates and provides data on both inhibition of maturation and re-invasion. METHODS: The method is based on the staining of parasites with hydroethidine (HE) and thiazole orange (TO) which allow differential identification of early, trophozoite and late stage of the parasite by flow cytometry. Late stages of the parasites are obtained by incubation in culture for 24 hours. Reinvasion is followed by culturing parasitized red blood cells for 24 h more. RESULTS: Compared to the standard [3H]-hypoxanthine incorporation assay, it gave similar results as expressed by 50% inhibitory concentrations for chloroquine of laboratory strains and "field" isolates. The effect of quinine on the schizont-ring transition was also explored using this method. First data on the inhibition of re-invasion induced by quinine are presented for both P. falciparum-cultured strains and field isolates. DISCUSSION: This method is simple to use event for field isolate study. It is suitable to analyse effect of drugs on steps of the parasite life cycle different for the maturation one. Using this method quinine was found to have a inhibitory effect on re-invasion of red cells by Plasmodium.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Madagascar</li>
<li>Sénégal</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Grenoble</li>
</settlement>
<orgName><li>Université Joseph Fourier</li>
<li>Université de Grenoble</li>
</orgName>
</list>
<tree><country name="Sénégal"><noRegion><name sortKey="Varela, Marie" sort="Varela, Marie" uniqKey="Varela M" first="Marie" last="Varela">Marie Varela</name>
</noRegion>
</country>
<country name="Madagascar"><noRegion><name sortKey="Razakandrainibe, Romy" sort="Razakandrainibe, Romy" uniqKey="Razakandrainibe R" first="Romy" last="Razakandrainibe">Romy Razakandrainibe</name>
</noRegion>
<name sortKey="Jambou, Ronan" sort="Jambou, Ronan" uniqKey="Jambou R" first="Ronan" last="Jambou">Ronan Jambou</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Aldebert, Delphine" sort="Aldebert, Delphine" uniqKey="Aldebert D" first="Delphine" last="Aldebert">Delphine Aldebert</name>
</region>
<name sortKey="Barale, Jean Christophe" sort="Barale, Jean Christophe" uniqKey="Barale J" first="Jean Christophe" last="Barale">Jean Christophe Barale</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000174 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000174 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:pasteur-00971508
   |texte=   Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study.
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study.

Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri